diff --git a/crates/languages/src/python/config.toml b/crates/languages/src/python/config.toml
index c58a54fc1cae78cfb3722e74008fe42c7a883851..d96a5ea5fefd0814c4b0787251e5cf6e4c166d5e 100644
--- a/crates/languages/src/python/config.toml
+++ b/crates/languages/src/python/config.toml
@@ -1,7 +1,7 @@
 name = "Python"
 grammar = "python"
 path_suffixes = ["py", "pyi", "mpy"]
-first_line_pattern = '^#!.*\bpython[0-9.]*\b'
+first_line_pattern = '^#!.*((\bpython[0-9.]*\b)|(\buv run\b))'
 line_comments = ["# "]
 autoclose_before = ";:.,=}])>"
 brackets = [